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For example, Januvia and Janumet, two of the three Merck drugs listed as TrumpRx presidential deals, are available as generics

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Post-translational modifications (PTMs) serve as sophisticated molecular switches that dynamically regulate protein structure, activity, subcellular localization, and functional interactions through covalent attachment of biochemical groups or regulatory subunits

Its also worth keeping in mind that there are other things that have decent evidence for both pain and the inflammatory picture in these conditions